在集约化养殖环境中，病理因素、不平衡的营养供给和管理不当常引发家禽氧化应激、肠道功能紊乱及亚健康，进而影响饲料效率和生产性能，造成经济损失。因此，提高肉鸡的抗氧化功能成为研究热点。槲皮万寿菊素（QG）已被证明能提高肉鸡表观消化率、改善小肠结构并增强免疫力。然而，关于QG对肉鸡肠道抗氧化功能及肠道菌群的影响尚缺乏系统研究。本研究旨在探讨QG对肉鸡生长性能、肠道抗氧化功能及肠道菌群多样性的调节作用，评估其在畜禽饲养中的应用潜力。
近期，河北工程大学生命科学与食品工程学院石玉祥团队完成的题为“The impact of dietary supplementation of Quercetagetin on growth, antioxidant capacity, and gut microbiota of diquat-challenged broilers”的研究论文在Frontiers in Microbiology（中科院2区，IF=4.0）上发表。
本研究探讨了QG对肉鸡氧化应激和肠道微生物群落的调节作用。不同剂量QG的添加显著改善了肉鸡的生长性能、增强了血清抗氧化能力，并减轻了肠道氧化应激损伤。QG的作用机制可能通过调节Nrf2/Keap1信号通路实现抗氧化效应。此外，QG优化了盲肠微生物群落的多样性和稳定性。研究结果为QG作为肉鸡日粮添加剂的应用提供了理论依据，旨在提升肉鸡的生长性能和肠道健康。
Fig. 1 Broiler experiment flow diagram.
DQ, Diquat; QG, Quercetagetin.
Fig.2 Effects of diets with different concentrations QG on antioxidant-related gene expression in the small intestine of broilers challenged with DQ (21 d).
Note: CON, control group; DQ, diquat group; LQG, low-dose quercetagetin group; MQG, medium-dose quercetagetin group; HQG, high-dose quercetagetin group. (A) Duodenum; (B) jejunum; (C) ileum. Bars represent the means±standard deviation (SD) (n=6). a,b Different letters in the shoulder markers in the table indicate significant differences between groups (P<0.05).
Fig. 3 Effects of diets with different concentrations of QG on cecal microbial alpha diversity of broilers challenged with DQ
A= OTUs; B= Chao1 index; C= Shannon index; D=Simpson index; E=Venn diagram of OTU. Bars represent the means±standard deviation (SD) (n=6).
a-b Different letters in the shoulder markers in the table indicate significant differences between groups (P< 0.05).
Fig. 4 Effects of different concentrations of QG in the diet on the relative abundance of cecal microbiota at the phylum (A) and genus (B) levels in broilers challenged with DQ (n=6).
Cecal microbiota composition at the phylum (A) and genus (B) levels of broilers.
Fig. 7 Correlation analyses between the Growth performance, oxidative function indicators and top 50 cecal bacterial genera (n=6).
The red squares represent the positive correlations while blue ones represent the negative correlations. *P<0.05; **P<0.01; ***P<0.001.
河北工程大学生命科学与食品工程学院石玉祥教授为该文章的通讯作者，杨硕为第一作者。本研究得到河北省自然然科学基金项目（C2022402040）的支持。
原文链接：https://doi.org/10.3389/fmicb.2024.1453145
Cite the article:
Yang, S., Huo, M., Su, Z.X., Wang, F.F., Zhang, Y.Y., Zhong, C.H., Shi, Y.X.* The impact of dietary supplementation of Quercetagetin on growth, antioxidant capacity, and gut microbiota of diquat-challenged broilers. Front. Microbiol. 2024. 15:1453145.
